Aprepitant

Aprepitant (brand name: Emend™) is a medication, that is used in the treatment of chemotherapy induced nausea / emesis.

It is a neurokinin 1 receptor antagonist, that blocks the effect of substance P. It mediates its effect via neurokinin 1 receptor that is an endogenous receptor for substance P.

This class of drugs are called substance P antagonits (SPA).