Category:Dihydrofolate reductase inhibitors

These agents inhibit the enzyme dihydrofolate reductase, an important rate-limiting step in the de novo folate synthesis pathway. Methotrexate is a cancer chemotherapeutic agent, whilst trimethoprim is an antibiotic. The reason for this disparity, despite both being dihydrofolate reductase inhibitors, is that methotrexate has a selective affinity for mammalian dihydrofolate reductase, while trimethoprim has a selective affinity for the bacterial enzyme.

Articles in category "Dihydrofolate reductase inhibitors"

There are 3 articles in this category.

M

• Methotrexate

P

• Pemetrexed

T

• Trimethoprim