Epiphanius ("clearly manifested") was the name of several early Christian scholars and ecclesiastics:
- Epiphanius of Salamis, bishop of Salamis in Cyprus, died 410, author of Panarion
- Epiphanius of Constantinople, died 535, Patriarch of Constantinople 520—535
- Epiphanius Scholasticus, known only as the assistant of Cassiodorus who compiled the Historiae Ecclesiasticae Tripartitae Epitome, ca. 510.
See also Antiochus IV Epiphanes, and Epiphanes a mid-2nd century Gnostic writer