Everolimus

Everolimus is a new mTOR inhibitor drug used as an immunosuppressant to prevent rejection of organ transplants. It is related to Sirolimus (Rapamycin), and works in the same way.

Everolimus may have a role in heart transplantation as it has been shown to reduce chronic allograft vasculopathy in such transplants. It also may have a similar role to sirolimus in kidney and other transplants.

Eisen HJ, Tuzcu EM, Dorent R, et al: Everolimus for the Prevention of Allograft Rejection and Vasculopathy in Cardiac-Transplant Recipients. New England Journal of Medicine 2003; 349:847-858