The piano composition Fantaisie-Impromptu, opus 66, by Frederic Chopin, is, arguably one of his most well-known pieces and one of the most famous works on classical piano. It is a deceivingly difficult piece, with many cross-rhythms (the right hand plays semiquavers against the left hand playing triplets) and a ceaselessly moving note figuration. However, it is known to "fit the hand" quite well and becomes substantially easier after a short time; large hands are immensely helpful when playing this piece.
It was said that Chopin disliked the piece. As a result, it was not published until after his death.