Indirect pathway of movement

The striatum modulates movement by two pathways: a direct pathway and an indirect pathway. In the indirect pathway, striatal neurons inhibit neurons in the globus pallidus externus , which in turn inhibit neurons in the subthalamic nucleus. The direct and indirect pathways then converge at the level of the globus pallidus internus with the excitation of neurons in this region by subthalamic neurons. As in the direct pathway, globus pallidus internus neurons inhibit thalamic neurons that excite the premotor cortex. The result of all these excitations and inhibitions is an inhibition of movement by the indirect pathway.