Melchior Josef Martin Knüsel (November 16, 1813 - January 15, 1889) was a Swiss politician.
He was elected to the Swiss Federal Council on July 14, 1855, and handed over office on December 31, 1875. He was affiliated with the Radicals. While in office he held the following departments:
He was President of the Confederation twice, in 1861 and 1866.