NTP binding site

An NTP binding site is a type of binding site found in NMP kinases, N can be adenosine or guanosine. A P-loop is one of the structural motifs common for NTP binding sites, it interacts with the bound nucleotide's phosphoryl groups. For the binding site to be able to bind a nucleotide, the nucleotide must be complex bound to Mg²⁺ og Mn²⁺. Nucleotide binding will cause conformational changes in the protein because the P-loop will bend.