The Nushagak River is a river in southwest Alaska, at about 60°50' North 154° West. It begins in the Alaska Range and flows southwest to 450 km (280 miles) to Nushagak Bay, an inlet of Bristol Bay, east of Dillingham, Alaska.
The upper part of the river is also called the Mulchatna River.
The village of Ekwok is on the river. The town of Dillingham is on Nushagak Bay.
Pacific salmon spawn in the river and both subsistence and sport fishing are important in the area.