Strategies for Engineered Negligible Senescence

Strategies for Engineered Negligible Senescence (SENS) is a plan designed by Aubrey de Grey to develop technologies that will prevent and reverse the progress of biological aging. Central to the strategies of this plan is the view that aging is caused by the accumulation of molecular and cellular damage. The objective of SENS is to develop treatments that are periodically applied to remove such accumulated damage. The philosophy of SENS, as stated by its author, is that knowledge of aging mechanisms is not as important as it is to obtain results, i.e it does not matter why it works, provided it works.

The SENS targets and proposed solutions are:

SENS target	Solution
Nuclear DNA mutations	Whole-body Interdiction of Lengthening of Telomeres
Mitochondrial DNA mutations	Allotopic expression of mitochondrial genes
Proliferation of unwanted cells	Whole-body Interdiction of Lengthening of Telomeres
Depletion of important cells	Stem cell therapeutics
Accumulation of intracellular waste	Xenolysozymes
Accumulation of extracellular waste	Immune modulation, synthetic peptide aggregate breakers
Accumulation of protein crosslinks	Synthetic peptide crosslink disruptors

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Categories: Aging