VMAT2

VMAT2 with VMAT1 are the two Isoforms of the Vesicular Monoamine Transporter protein.

Cocaine users display a marked reduction in VMAT2 immunoreactivity . Suffers of cocaine-induced mood disorders displayed a greater loss of VMAT2 immunoreactivity that approached significance, this might reflect damage to striatal dopamine fibers . These neuronal changes could play a role in causing disordered mood and motivational processes in more severely dependent users.

External links

• http://ajp.psychiatryonline.org/cgi/content/full/160/1/47