Valpromide

Valpromide (dipropylacetamide, α-propylvaleramide, Diprozin) is a carboxamide derivative of valproic acid that is considered safer to use than either valproic acid or sodium valproate. It is better tolerated and does not show as many side effects as sodium valproate. In particular, it is less likely to cause liver damage or cause birth defects when used by pregnant women.

Valpromide is formed through the reaction of valproic acid and ammonia via an intermediate acid chloride (such as HCl).

In pure form, valpromide is a white crystalline powder and has melting point 125-126°C. It is practically insoluble in water but soluble in hot water. It is available on the market in some European countries.

External link

• The Lundbeck Institute Guide to Psychotropics - Valpromide